Includes bibliographies and index.
|Statement||edited by P.H. Bach and E. Lock.|
|Series||Developments in nephrology, Developments in nephrology (Unnumbered)|
|Contributions||Bach, P. H., Lock, E. A.|
|The Physical Object|
|Pagination||2 v. :|
|ISBN 10||0746200382, 0746200390|
Nephrotoxicity in the experimental and clinical situation. Dordrecht ; Boston: M. Nijhoff ; Norwell, MA, USA: Distributors for the U.S. and Canada, Kluwer Academic, (OCoLC) Online version: Nephrotoxicity in the experimental and clinical situation. Nephrotoxicity in the experimental and clinical situation Part 1. Editors (view affiliations) P. H. Bach; E. A. Lock Search within book. Front Matter. Pages i-xi. PDF. Fixation of Renal Tissue for Cytochemical Evaluation Metabolic Activation of Halogenated Chemicals and its Relevance to Nephrotoxicity. E. A. Lock. Pages Back. Nephrotoxicity in the Experimental and Clinical Situation. by. Developments in Nephrology (Book ) Share your thoughts Complete your review. Tell readers what you thought by rating and reviewing this book. Rate it * You Rated it *Brand: Springer Netherlands. ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: Light hydrogen nephropathy and renal carcinoma Metallothionein and its involvement in heavy metal induced nephropathy Detection of nephrotoxicity of foreign chemicals with the use of in vitro and in vivo techniques Proteins, enzymes and cells in urine as indicators of.
Nephrotoxicity is a major reason for drug withdrawal post-market, indicating that the current clinical biomarkers and preclinical tests used to detect kidney injury are not sensitive enough and inadequate. Numerous toxicogenomics studies, including transcriptomics, proteomics, and metabolomics, have been performed by both industry and academia. There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or. Nephrotoxicity in the Experimental and Clinical Situation: Part 1 by Edward A. L Nephrotoxicity in the $ in Experimental the Nephrotoxicity Edward A. and by Part L Situation: Clinical 1 1 L Clinical Situation: in and by A. Experimental Part Nephrotoxicity the Edward. Description. Condition: Neu. Neuware - Nephrotoxicity should not be confused with the fact that some medications have a predominantly renal excretion and need their dose adjusted for the decreased renal function. Drug-induced nephrotoxicity can lead to acute kidney injury(AKI) or chronic kidney disease in patients and is a major problem for clinicians.
Drug-induced nephrotoxicity tends to be more common among certain patients and in specific clinical situations. Therefore, successful prevention requires knowledge of pathogenic mechanisms of Cited by: Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, ).These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of Cited by: Nephrotoxicity is toxicity in the is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. There are various forms, and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.. Nephrotoxicity should not be confused with the fact that some medications are predominantly excreted by. METHODS: We reviewed clinical and experimental literature on cisplatin nephrotoxicity to identify new information on the mechanism of injury and potential approaches to prevention and/or treatment. RESULTS: Unbound cisplatin is freely filtered at the glomerulus and taken up into renal tubular cells mainly by a transport-mediated by: